Analytical Review: Human Gamma Globulin

Human Gamma Globulin.

Structural units of human 7S gamma globulin.

Gamma globulin prophylaxis.

THE importance of infectious hepatitis as a world-wide problem has been highlighted in detail during the presentations made at this symposium. It is clear that as of today (May I 8, I968) there is no published report confirming the isolation of infectious hepatitis virus in a tissue-culture system or animal host. Experience with poliomyelitis, measles, and rubella has revealed that the time int...

Immunoglobulin Components of "gamma" Globulin in Human Serum.

Forty blood samples were obtame(1 from 36 subjects who ranged ill age from 3 days to 43 years. All subjects were examined! on tile day blood was drawn; the health of each was noted. Each serum sample was analyzed for immunoglobulins y G, y A, aIld y M by the agar gel precipitation method described by Claman and Merrill (2). In this test, serum is layered over a column of agar containing an anti...

Human gamma globulin fractionation on anion exchange cellulose columns.

The serum proteins designated as y-globulins include all proteins of the slowest moving of the several major protein groups seen on serum electrophoresis conducted at alkaline pH (2). Among the y-globulins of normal serum are proteins of differing electrophoretic mobility (3,4), proteins with sedimentation coefficients of 6.6 S and 18 S in the ultracentrifuge (2, 3, 5, 6)) many individual antib...